Same DNA, different disease in different cells: DeepMind's AlphaGenome 2 predicts which cells a mutation hits, free for research
AlphaGenome 2 is Google DeepMind's new DNA sequence model. You give it a stretch of DNA plus a target condition, a tissue, cell type or cell state, either picked from a reference catalog or built from your own single-cell experiment, and it predicts how a genetic variant changes gene expression, chromatin accessibility, histone marks and now DNA methylation in that specific cell. DeepMind says it was trained on more than 100 million single-cell profiles across 68 tissues and finds nearly twice as many expression-changing variants as the previous model. It can also predict measurements you didn't take, to help decide which experiment to run next.
Why it matters
Many disease variants only matter in one cell type, which broad tissue-level models miss; this gives researchers a free, finer-grained way to prioritise which variants and experiments to chase.
Who it's for
Geneticists, computational biologists, and students or academic labs working on variant interpretation and single-cell data.
How to try it
- Read DeepMind's AlphaGenome 2 post and request or use access through the AlphaGenome API for non-commercial research.
- Choose the cell type or state you care about from the reference catalog, or encode your own single-cell data.
- Score your candidate variants for that condition and compare against a broad-tissue baseline.
- Use the imputed readouts to pick the next wet-lab experiment, and validate before drawing conclusions.
Plan & availability: Available now for non-commercial research via the AlphaGenome API; commercial research is in private preview. Research use only, not for clinical or diagnostic decisions. Checked on deepmind.google on November 11, 2026.
Source: Google DeepMind on deepmind.google ↗
Written by AgentStackList from the original post. Checked Nov 11, 2026. Features, plans and availability can change, so confirm on the source before you rely on it.
deepmindalphagenomegenomicssciencefree-for-research
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